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KMID : 0357319950300060727
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Journal of the Korean Society for Microbiology
1995 Volume.30 No. 6 p.727 ~ p.736
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Molecular Characteristics of Oncogenes and p53 Antioncogene in Koera Colorectal Cancers
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Abstract
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To define the role of cellular oncogenes and tumor suppressor genes in human colorectal cancers, genetic alterations of ras, myc, fos oncogenes and p53 antioncogene in 30 freshly isolated primary colorectal cancer tissues were studied by using
various
molecular methods. In Southern blot hybridization, modest amplifications of c-myc gene(40%) were found in cancer tissues but no amplification and rearrangement of c-Ha-ras, and p53 genes were observed. In RNA slot blot analysis, 47% of cases
showed
significantly elevated expression of c-myc gene and 12% of cases showed modest elevated level of c-Ha-ras gene transcripts. These results suggested that amplification/overexpression of c-myc gene and elevated expression of c-Ha-ras gene were
involved in
tumor development of Korcan colorectal cancers.
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KEYWORD
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